Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis
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منابع مشابه
Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis.
Asbestos has been described as a physical carcinogen in that its carcinogenic effects appear to be related primarily to fiber dimensions. It has been hypothesized that long asbestos fibers may interfere with chromosome distribution during cell division, causing genomic changes that lead to cell transformation and neoplastic progression. Using high-resolution time-lapse light microscopy and seri...
متن کاملCytotoxicity of Long and Short Crocidolite Asbestos Fibers
Fiber length and diameter are important factors in the pathogenicity of asbestos. We examined the relative toxicity of long and short crocidolite asbestos fibers in vitro and in vivo. Both long and short crocidolite asbestos fibers were toxic to elicited macrophages in vitro. Similar to native crocidolite asbestos, long and short Tibers stimulated the release of reactive oxygen metabolites from...
متن کاملCytotoxicity of Long and Short Crocidolite Asbestos Fibers in Vitro and in Vivo1
Fiber length and diameter are important factors in the pathogenicity of asbestos. We examined the relative toxicity of long and short crocidolite asbestos fibers in vitro and in vivo. Both long and short crocidolite asbestos fibers were toxic to elicited macrophages in vitro. Similar to native crocidolite asbestos, long and short Tibers stimulated the release of reactive oxygen metabolites from...
متن کاملCytotoxicity of long and short crocidolite asbestos fibers in vitro and in vivo.
Fiber length and diameter are important factors in the pathogenicity of asbestos. We examined the relative toxicity of long and short crocidolite asbestos fibers in vitro and in vivo. Both long and short crocidolite asbestos fibers were toxic to elicited macrophages in vitro. Similar to native crocidolite asbestos, long and short fibers stimulated the release of reactive oxygen metabolites from...
متن کاملSusceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.
Exposure of mesothelial cells to asbestos fibers in vitro has been shown to induce DNA damage mediated by oxidants. An early cellular response to DNA damage is increased expression of the p53 protein. This protein induces transcription of genes that activate cell cycle checkpoints or induce apoptosis. A murine mesothelial cell line that spontaneously acquired a point mutation in the p53 gene sh...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1996
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/17.9.2013